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Photo of Kevin Plaxco

Kevin Plaxco

ICB Biotechnology Tools Co-Leader
Director, Center for Bioengineering 
Professor
Chemistry & Biochemistry
UC Santa Barbara
Phone:
+1 805-893-5558
Email:
kwp@chem.ucsb.edu
Website:
[Add Website Name]

We are developing a broad class of optical and electronic (electrochemical) biosensors based on the binding-induced folding of proteins, peptides and DNA. These sensors are sensitive (to femtomolar), specific, rapid (minutes) and selective enough to deploy directly in serum, foodstuffs and other grossly contaminated materials.

Displaying 1 - 20 of 25

ICB Supported Publications

High-Precision Control of Plasma Drug Levels Using Feedback-Controlled Dosing

Netzahualcóyotl Arroyo-Currás, Gabriel Ortega, David A. Copp, Kyle L. Ploense, Zoe A. Plaxco, Tod E. Kippin, João P. Hespanha and Kevin W. Plaxco
CS Pharm. Trans. Sci.,
10.1021/acsptsci.8b00033

Electrochemical Aptamer-Based Sensors for Rapid Point-of-Use Monitoring of the Mycotoxin Ochratoxin A Directly in a Food Stream

Jacob Somerson and Kevin W. Plaxco
Molecules,
10.3390/molecules23040912

Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

Anna J. Simon, Luke T. Walls-Smith, Kevin W. Plaxco
Analyst,
10.1039/C8AN00337H

Subsecond-Resolved Molecular Measurements in the Living Body Using Chronoamperometrically Interrogated Aptamer-Based Sensors

Netzahualcoyotl Arroyo-Currás, Philippe Dauphin-Ducharme, Gabriel Ortega, Kyle L. Ploense, Tod E. Kippin and Kevin W. Plaxco
ACS Sensors,
10.1021/acssensors.7b00787

High Surface Area Electrodes Generated via Electrochemical Roughening Improve the Signaling of Electrochemical Aptamer-Based Biosensors

Netzahualcóyotl Arroyo-Currás, Karen Scida, Kyle L. Ploense, Tod E. Kippin and Kevin W. Plaxco
Analytical Chemistry,
10.1021/acs.analchem.7b02830

Calibration-free electrochemical biosensors supporting accurate molecular measurements directly in undiluted whole blood

Li, H., Dauphin-Ducharme, P., Ortega, G. and Plaxco, K.W.
Journal of the American Chemical Society,
10.1021/jacs.7b05412

A biomimetic, phosphatidylcholine- terminated monolayer greatly improves the in-vivo performance of electrochemical aptamer-based sensors

Li, H., Dauphin-Ducharme, P., Arroyo-Currás, N., Tran, C., Vieira, P.A., Li, S., Shin, C., Somerson, J., Kippin, T.E. and Plaxco, K.W.
Angewandte Chemie, International Edition,
10.1002/anie.201700748

Real-time measurement of small molecules directly in awake, ambulatory animals

Arroyo-Currás, N., Somerson, J., Vieira, P., Ploense, K., Kippin, T. and Plaxco, K.W.
Proceedings of the National Academy of Science,
10.1073/pnas.1613458114

Simultaneous measurement of the dissolution kinetics of responsive DNA hydrogels at multiple length scales

Simon, A.J., Walls-Smith, L.T., Freddi, M., Fong, F.Y., Gubala, V. and Plaxco, K.W.
ACS Nano,
10.1021/acsnano.6b06414

Dual-reporter drift correction to enhance the performance of electrochemical aptamer-based sensors in whole blood

Li, H., Arroyo-Currás, N., Kang, D., Ricci, F. and Plaxco, K.W.
Journal of the American Chemical Society,
10.1021/jacs.6b08671

Maximizing the signal gain of electrochemical-DNA sensors

Daupin-Ducharme, P. and Plaxco, K. W.
Analytical Chemistry,
10.1021/acs.analchem.6b03227

Survey of redox-active moieties for application in multiplexed electrochemical biosensors

Kang, D., Ricci, F., White, R.J. and Plaxco, K.W.
Analytical Chemistry,
10.1021/acs.analchem.6b02376

Using Nature’s ‘tricks’ to rationally tune the binding properties of biomolecular receptors

Ricci, F., Vallée-Bélisle, A., Simon, A.J., Porchetta, A. and Plaxco, K.W.
Accounts of Chemical Research,
10.1021/acs.accounts.6b00276

Integrated electrochemical microsystems for genetic detection of pathogens at the point of care

K. Hsieh, B. S. Ferguson, M. Eisenstein, K. W. Plaxco, and H. T. Soh
Accounts of Chemical Research,
10.1021/ar500456w

Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors

A. J. Simon, A. Vallée-Bélisle, F. Ricci, and K. W. Plaxco
PNAS,
10.1073/pnas.1410796111

Accurate zygote-specific discrimination of single-nucleotide polymorphisms using microfluidic electrochemical DNA melting curves

A. H. J. Yang, K. Hsieh, A. S. Patterson, B. S. Ferguson, M. Eisenstein, K. W. Plaxco, and H. T. Soh
Angew. Chemie Int. Ed.,
10.1002/anie.201310059

A comparison of the folding kinetics of a small, artificially selected DNA aptamer with those of equivalently simple naturally occurring proteins

C. Lawrence, A. Vallée-Bélisle, S. H. Pfeil, D. de Mornay, E. A Lipman, and K. W. Plaxco
Protein Sci.,
10.1002/pro.2390

Real-time, aptamer-based tracking of circulating therapeutic agents in living animals

B. S. Ferguson, D. A. Hoggarth, D. Maliniak, K. Ploense, R. J. White, N. Woodward, K. Hsieh, A. J. Bonham, M. Eisenstein, T. E. Kippin, K. W. Plaxco, and H. T. Soh
Science Translational Medicine,
10.1126/scitranslmed.3007095

Microfluidic chip-based detection and intraspecies strain discrimination of salmonella serovars derived from whole blood of septic mice

A. S. Patterson, D. M. Heithoff, B. S. Ferguson, H. T. Soh, M. J. Mahan, and K. W. Plaxco
Applied and Environmental Microbiology,
10.1128/AEM.03882-12

Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care through microfluidic electrochemical quantitative loop-mediated isothermal amplification

K. Hsieh, A. Patterson, B. Ferguson, K. Plaxco, and H. Soh
Angewandte Chemie International Edition,
10.1002/anie.201109115
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