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Photo of Richard Murray

Richard Murray

ICB Caltech Program Leader
ICB Systems and Synthetic Biology Co-Leader
Division Chair and Professor
Control & Dynamical Systems
Bioengineering
Caltech
Phone:
+1 626-395-6460
Email:
murray@cds.caltech.edu
Website:
Website

Research Focus Areas

Research Interests

Application of feedback and control to networked systems, with applications in biology and autonomy.  Design and verification of distributed embedded systems, analysis of insect flight control systems, and biological circuit design.

National Academies

NAE 2013

News

Displaying 1 - 20 of 25

ICB Supported Publications

Development of cell-free transcription-translation systems in three soil Pseudomonads

J. T. Meyerowitz, E. M. Larsson, R. M. Murray
ACS Synthetic Biology,
10.1021/acssynbio.3c00468

Engineering the Soil Bacterium Pseudomonas synxantha 2−79 into a Ratiometric Bioreporter for Phosphorus Limitation

Elin M. Larsson, Richard M. Murray, and Dianne K. Newman
ACS Synthetic Biology,
10.1021/acssynbio.3c00642

A 65-nm CMOS Fluorescence Sensor for Dynamic Monitoring of Living Cells

Fatemeh Aghlmand, Chelsea Y. Hu, Saransh Sharma, Krishna Pochana, Richard M. Murray and Azita Emami
IEEE Journal of Solid-State Circuits,
10.1109/JSSC.2023.3308853

Addressable and adaptable intercellular communication via DNA messaging

John P. Marken and Richard M. Murray
Nature Communications,
10.1038/s41467-023-37788-z

A 65nm CMOS Living-Cell Dynamic Fluorescence Sensor with 1.05fA Sensitivity at 600/700nm Wavelengths

Fatemeh Aghlmand, Chelsea Hu, Saransh Sharma, Krishna K. Pochana, Richard M. Murray, Azita Emami
Proceeding of 2023 IEEE Solid State Circuits Conference (ISSCC),
10.1109/ISSCC42615.2023.10067325

Characterization of Integrase and Excisionase Activity in Cell-free Protein Expression System Using a Modeling and Analysis Pipeline

Ayush Pandey, Makena L. Rodriguez, William Poole and Richard M. Murray
ACS Synthetic Biology,
10.1021/acssynbio.2c00534

Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli

Rory L. Williams and Richard M. Murray
Nature Communications,
10.1038/s41467-022-34361-y

BioCRNpyler: Compiling chemical reaction networks from biomolecular parts in diverse contexts.

William Poole, Ayush Pandey, Andrey Shur, Zoltan A. Tuza, Richard M. Murray
PLOS Computational Biology,
10.1371/journal.pcbi.1009987

Modeling Dynamic Transcriptional Circuits with CRISPRi

Samuel Clamons, Richard M. Murray
bioRxiv,
10.1101/225318

Proof of concept continuous event logging in living cells

Andrey Shur, Richard M. Murray
bioRxiv ,
10.1101/225151

Analysis of Circuits for Dosage Control in Microbial Populations

Sophie J. Walton, Samuel E. Clamons, Richard M. Murray
bioRxiv,
10.1101/2020.12.18.423556

A Method for Cost-Effective and Rapid Characterization of Engineered T7-based Transcription Factors by Cell-Free Protein Synthesis Reveals Insights into the Regulation of T7 RNA Polymerase-Driven Expression

John B. McManus, Richard M. Murray, Peter A. Emanuel, Matthew W. Lux
Archives of Biochemistry and Biophysics,
10.1016/j.abb.2019.07.010

Addressable, “Packet-Based” Intercellular Communication through Plasmid Conjugation

John P. Marken, Richard M. Murray
qBio Conference,
10.1101/591552

Tunable integrase-mediated differentiation facilitates improved output of burdensome functions in E. coli

Rory L. Williams, Richard M. Murray
Synthetic Biology: Engineering, Evolution and Design (SEED) Conference),
10.1101/614529

Length and time scales of cell-cell signaling circuits in agar

Joy Doong, James Parkin, Richard M. Murray
Winter q-bio Conference,
10.1101/220244

A population-based temporal logic gate for timing and recording chemical events

Hsiao, V., Hori, Y., Rothemund, P. W. K. and Murray R. M.
Molecular Systems Biology,
10.15252/msb.20156663

Engineering transcriptional regulator effector specificity using computational design and in vitro rapid prototyping: Developing a vanillin sensor

de los Santos, E. L. C., Meyerowitz, J. T., Mayo, S. L. and Murray, R. M.
ACS Synthetic Biology,
10.1021/acssynbio.5b00090

Design and implementation of a synthetic biomolecular concentration tracker

V. Hsiao, E. L. C. de los Santos, W. R. Whitaker, J. E. Dueber, and R. M. Murray
ACS Synthetic Biology,
10.1021/sb500024b

Reverse engineering combination therapies for evolutionary dynamics of disease: An H∞ approach

V. Jonsson, N. Matni, and R. M. Murray
Proceedings of the 52nd IEEE Conference on Decision and Control,

Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response

O. S. Venturelli, H. El-Samad, and R. M. Murray
Proceedings of the National Academy of Sciences,
10.1073/pnas.1211902109
Emblems