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Photo of Mark Bathe

Mark Bathe

Professor
Biological Engineering
MIT
Phone:
+1 617-324-5685
Email:
mbathe@mit.edu
Website:
Website
Twitter Link:
@bathe_mark

Research Focus Areas

Research Interests

Our lab is interested in developing DNA and RNA based materials with revolutionary properties for applications including quantum sensing and computing, light-harvesting, carbon sequestration, molecular memory, and therapeutic delivery. DNA is highly programmable structurally due to its robust Watson-Crick base-pairing rules, and its synthetic nature. In contrast, RNA is active catalytically and interfaces naturally with a range of RNA-binding proteins, as well as DNA. Together, they form versatile hybrid nanoscale materials with the ability to rationally design a range of 2D and 3D structured materials with unusual properties that we are investigating using imaging, computation, spectroscopy, and cell-based assays.

News

Displaying 1 - 12 of 12

ICB Supported Publications

Ultrafast dense DNA functionalization of quantum dots and rods for scalable 2D array fabrication with nanoscale precision

Chi Chen, Xin Luo, Alexander E. K. Kaplan, Moungi G. Bawendi, Robert J. Macfarlane and Mark Bathe
Science Advances,
10.1126/sciadv.adh8508

Isometric Hamming embeddings of weighted graphs

Joseph Berleant, Kristin Sheridan, Anne Condon, Virginia Vassilevska Williams, Mark Bathe
Discrete Applied Mathematics ,
10.1016/j.dam.2023.02.005

Activating charge-transfer state formation in strongly-coupled dimers using DNA scaffolds

Stephanie M. Hart, James L. Banal, Maria A. Castellanos, Larysa Markova, Yuliia Vyborna, Jeffrey Gorman, Robert Häner, Adam P. Willard, Mark Bathe and Gabriela S. Schlau-Cohen
Chemical Science,
10.1039/d2sc02759c

Planar 2D Wireframe DNA Origami

Xiao Wang, Shanshan Li, Hyungmin Jun, Torsten John, Kaiming Zhang, Hannah Fowler, Jonathan P.K. Doye, Wah Chiu and Mark Bathe
Science Advances,
10.1126/sciadv.abn0039

Programming 2D Supramolecular Assemblies with Wireframe DNA Origami

Xiao Wang, Hyungmin Jun, and Mark Bathe
Journal of the American Chemical Society,
10.1021/jacs.1c11332

Tuning Optical Absorption and Emission Using Strongly Coupled Dimers in Programmable DNA Scaffolds

Stephanie M. Hart, Xiao Wang, Jiajia Guo, Mark Bathe, and Gabriela S. Schlau-Cohen
The Journal of Physical Chemistry Letters,
10.1021/acs.jpclett.1c03848

Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami

Hyungmin Jun, Xiao Wang, Molly F Parsons, William P Bricker, Torsten John, Shanshan Li, Steve Jackson, Wah Chiu, Mark Bathe
Nucleic Acids Research,
10.1093/nar/gkab762

Random access DNA memory using Boolean search in an archival file storage system

Banal, J.L., Shepherd, T.R., Berleant, J.D., Huang, H., Reyes, M., Ackerman, C.M., Blainey, P.C., Bathe, M.
Nature Materials,
10.1038/s41563-021-01021-3

Engineering couplings for exciton transport using synthetic DNA scaffolds

Stephanie M. Hart, Wei-Jia Chen, James L. Banal, William P. Bricker, Amro Dodin, Larysa Markova, Yuliia Vyborna, Adam P. Willard, Robert Häner, Mark Bathe, Gabriela S. Schlau-Cohen
Chem,
10.1016/j.chempr.2020.12.020

Rapid Prototyping of Wireframe Scaffolded DNA Origami using ATHENA

Hyungmin Jun, Xiao Wang, William P. Bricker, Steve Jackson, Mark Bathe
bioRxiv,
10.1101/2020.02.09.940320

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

Rémi Veneziano, Tyson J. Moyer, Matthew B. Stone, Eike-Christian Wamhoff, Benjamin J. Read, Sayak Mukherjee, Tyson R. Shepherd, Jayajit Das, William R. Schief, Darrell J. Irvine, Mark Bathe
Nature Nanotechnology,
10.1101/2020.02.16.951475

Automated sequence design of 2D wireframe DNA origami with honeycomb edges

Hyungmin Jun, Xiao Wang, William P. Bricker and Mark Bathe.
Nature Communications,
10.1038/s41467-019-13457-y
Emblems