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Photo of Dennis Clegg

Dennis Clegg

Professor
Molecular, Cellular & Developmental Biology
UC Santa Barbara
Phone:
+1 805-893-8490
Email:
clegg@lifesci.ucsb.edu
Website:
[Add Website Name]

Differentiation of ocular cells from embryonic and adult stem cells; Synthetic matrices for stem cell growth and differentiation. Molecular basis of neural development and disease; retinal development and degeneration.

Displaying 1 - 14 of 14

ICB Supported Publications

Adipose Stem Cells Incorporated in Fibrin Clot Modulate Expression of Growth Factors

Kelsy R. Siegel, Tracy N. Clevenger, Dennis O. Clegg, Duncan A. Proctor and Christopher S. Proctor
Arthroscopy: The Journal of Arthroscopic & Related Surgery,
10.1016/j.arthro.2017.08.250

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

Germán G Gornalusse, Roli K Hirata, Sarah E Funk, Laura Riolobos, Vanda S Lopes, Gabriel Manske, Donna Prunkard, Aric G Colunga, Laïla-Aïcha Hanafi, Dennis O Clegg, Cameron Turtle and David W Russell
Nature Biotechnology,
10.1038/nbt.3860

Induced pluripotent stem cell-derived retinal pigmented epithelium: a comparative study between cell lines and differentiation methods

Leach, L. L., Croze, R. H., Hu, Q., Nadar, V. P., Clevenger, T. N., Gamm, D. M. and Clegg, D. O.
Journal of Ocular Pharmacology and Therapeutics,
10.1089/jop.2016.0022

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs

Koss, M. J., Falabella, P., Stefanini, F. R., Pfister, M., Chader, G. J., Thomas, B. B., Thomas, P., Kashani, A. H., Brant, R., Hikita, S. T., Johnson, L. V., Clegg, D. O., Zhu, D., Hinton, D. R. and Humayun, M. S.
Graefe's Archive for Clinical and Experimental Ophthalmology,
10.1007/s00417-016-3386-y

Vitronectin-based, biomimetic encapsulating hydrogel scaffolds support adipogenesis of adipose stem cells

Clevenger, T.N., Hinman, C.R., Rubin, R.K.A., Smither, K., Burke, D.J., Hawker, C.J., Messina, D., Van Epps, D. and Clegg, D.O.
Tissue Engineering Part A,
10.1089/ten.tea.2015.0550

Concise review: Making stem cells retinal: Methods for deriving retinal pigment epithelium and implications for patients with ocular disease

L. L. Leach and D. O. Clegg
Stem Cells,
10.1002/stem.2010

Cellular models and therapies for age-related macular degeneration

D. L. Forest, L. V. Johnson, and D. O. Clegg
Disease Models & Mechanisms,
10.1242/dmm.017236

Canonical/β-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells

L. L. Leach, D. E. Buchholz, V. P. Nadar, S. E. Lowenstein, and D. O. Clegg
Nanotechnology and Regenerative Medicine,
10.1167/iovs.14-15835

Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate

B. O. Pennington, D. O. Clegg, Z. K. Melkoumian, and S. T. Hikitaa
Stem Cells Translational Medicine,
10.5966/sctm.2014-0179

Reprogramming human retinal pigmented epithelial cells to neurons using recombinant proteins

Q. Hu, R. Chen, T. Teesalu, E. Ruoslahti, and D. O. Clegg
Stem Cells Translational Medicine,
10.5966/sctm.2014-0038

Light-activated RNA interference in human embryonic stem cells

X. Huang, Q. Hu, G. B. Braun, A. Pallaoro, D. P. Morales, J. Zasadzinski, D. O. Clegg, and N. O. Reich
Biomaterials,
10.1016/j.biomaterials.2015.06.006

ROCK inhibition extends passage of pluripotent stem cell-derived retinal pigmented epithelium

R. H. Croze, D. E. Buchholz, M. J. Radeke, W. J. Thi, Q. Hu, P. J. Coffey, and D. O. Clegg
Stem Cells Translational Medicine,
10.5966/sctm.2014-0079

Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium

D. E. Buchholz, B. O. Pennington, R. H. Croze, C. R. Hinman, P. J. Coffey, and D. O. Clegg
10.5966/sctm.2012-0163

Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins

T. Rowland, A. Blaschke, D. Buchholz, S. Hikita, L. Johnson, and D. Clegg
Journal of Tissue Engineering and Regenerative Medicine,
10.1002/term.1458
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