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Photo of David Tirrell

David Tirrell

Provost and Larson Provostial Chair
McCollum-Corcoran Professor
Chemistry and Chemical Engineering
Caltech
Phone:
+1 626-395-3140
Email:
tirrell@caltech.edu
Website:
Website

Research Focus Areas

Research Interests

Combination of organic, biological, and materials chemistry to make new polymeric systems of controlled molecular and supramolecular architectures. Investigation of artificial proteins made by expression of artificial genes in microbial cells, artificial amino acids to engineer proteins with useful properties, and novel methods of biological imaging and proteome-wide investigation of cellular processes.

National Academies

NAS 2006, NAE 2008, NAM 2011, NAI 2018

News

Displaying 1 - 20 of 23

ICB Supported Publications

Tidyproteomics: an open-source R package and data object for quantitative proteomics post analysis and visualization

Jeff Jones, Elliot J. MacKrell, Ting-Yu Wang, Brett Lomenick, Michael L. Roukes and Tsui-Fen Chou
BMC Bioinformatics,
10.1186/s12859-023-05360-7

Staphylococcal secreted cytotoxins are competition sensing signals for Pseudomonas aeruginosa

Grace Z. Wang, Elizabeth A. Warren, Allison L. Haas, Andrea Sánchez Peña, Megan R. Kiedrowski, Brett Lomenick, Tsui-Fen Chou, Jennifer M. Bomberger, David A. Tirrell, Dominique H. Limoli
bioRxiv,
10.1101/2023.01.29.526047

3D-printable cellular composites for production of recombinant proteins

Seunghyun Sim, Yue Hui and David A. Tirrell
Bio Macromolecules,
10.1021/acs.biomac.2c00915

Stress-tolerant, recyclable, and renewable biocatalyst platform enabled by engineered bacterial spores

Yue Hui, Ziyu Cui and Seunghyun Sim
ACS Synthetic Biology,
10.1021/acssynbio.2c00256

The dormancy-specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa

Megan Bergkessel, Brett M. Babin, David VanderVelde, Michael J. Sweredoski, Annie Moradian, Roxana Eggleston-Rangel, Sonja Hess, David A. Tirrell, Irina Artsimovitch and Dianne K. Newman
Molecular Microbiology,
10.1111/mmi.14337

Selective Proteomic Analysis of Antibiotic-Tolerant Cellular Subpopulations in Pseudomonas aeruginosa Biofilms

Brett M. Babin, Lydia Atangcho, Mark B. van Eldijk, Michael J. Sweredoski, Annie Moradian, Sonja Hess, Tim Tolker-Nielsen, Dianne K. Newman and David A. Tirrell
mBio,
10.1128/mBio.01593-17

Cell-selective proteomics for biological discovery

Stone, S.E., Glenn, W.S., Hamblin, G.D. and Tirrell, D.A.
Current Opinion in Chemical Biology,
10.1016/j.cbpa.2016.12.026

Chemoenzymatic labeling of proteins for imaging in bacterial cells

Ho, S.H. and Tirrell, D.A.
Journal of the American Chemical Society,
10.1021/jacs.6b07067

Engineered aminoacyl- tRNA synthetase for cell-selective analysis of mammalian protein synthesis

Mahdavi, A., Hamblin, G.D., Jindal, G.A., Bagert, J.D., Dong, C., Sweredoski, M.J., Hess, S., Schuman, E.M. and Tirrell, D.A.
Journal of the American Chemical Society,
10.1021/jacs.5b08980

SutA is a bacterial transcription factor expressed during slow growth in Pseudomonas aeruginosa

Babin, B. M., Bergkessel, M., Sweredoski, M. J., Moradian, A., Hess, S., Newman, D. K. and Tirrell, D. A.
PNAS,
10.1073/pnas.1514412113

Time-resolved proteomic analysis of quorum sensing in Vibrio harveyi

Bagert, J. D., van Kessel, J. C., Sweredoski, M. J., Feng, L., Hess, S., Bassler, B. L. and Tirrell, D. A.
Chemical Science,
10.1039/C5SC03340C

A Qrr noncoding RNA deploys four different regulatory mechanisms to optimize quorum-sensing dynamics

L. Feng, S. T. Rutherford, K. Papenfort, J. D. Bagert, J. C. van Kessel, D. A. Tirrell, N. S. Wingreen, and B. L. Bassler
Cell,
10.1016/j.cell.2014.11.051

Quantitative, time-resolved proteomic analysis by combining bioorthogonal noncanonical amino acid tagging and pulsed stable isotope labeling by amino acids in cell culture

J. D. Bagert, Y. J. Xie, M. J. Sweredoski, Y. Qi, S. Hess, E. M. Schuman, and D. A. Tirrell
Mol. Cell. Proteomics,
10.1074/mcp.M113.031914

Chemical tools for temporally and spatially resolved mass spectrometry-based proteomics

K. P. Yuet and D. A. Tirrell
Ann. Biomed. Eng.,
10.1007/s10439-013-0878-3

Identification of secreted bacterial proteins by noncanonical amino acid tagging

A. Mahdavi, J. Szychowski, J. T. Ngo, M. J. Sweredoski, R. L. J. Graham, S. Hess, O. Schneewind, S. K. Mazmanian, and D. A. Tirrel
Proc. Natl. Acad. Sci. U.S.A.,
10.1073/pnas.1301740111

Mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells

J. T. Ngo, E. M. Schuman, and D. A. Tirrell
10.1073/pnas.1216375110

State-Selective Metabolic Labeling of Cellular Proteins

J. T. Ngo, B. M. Babin, J. A. Champion, E. M. Schuman, and D. A. Tirrell
 ACS Chemical Biology,
10.1021/cb300238w

Two-strain, cell-selective protein labeling in mixed bacterial cultures

F. Truong, T. Yoo, T. Lampo, and D. Tirrell
Journal of the American Chemical Society,
10.1021/ja3004667

Noncanonical amino acids in the interrogation of cellular protein synthesis

J. Ngo and D. Tirrell
Accounts of Chemical Research,
10.1021/ar200144y

A BODIPY-cyclooctyne for protein imaging in live cells

K. Beatty, J. Szychowski, J. Fisk, and D. Tirrell
ChemBioChem,
10.1002/cbic.201100277
Emblems